pentobarbital will reduce the level or impact of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or impact of ixabepilone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Induction of microsomal enzymes by this drug, may shorten the half-life of doxycyclin